Atsushi Sugiyama Selected Research

Halothane (Fluothane)

1/2021	Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.
1/2020	Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs.
12/2017	Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
2/2016	Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.
1/2016	Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs.
7/2015	Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes.
6/2015	Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.
4/2006	Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
10/2004	Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.
5/2004	Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.

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Atsushi Sugiyama Research Topics

Disease

36	Atrioventricular Block 01/2023 - 08/2002
32	Torsades de Pointes (Torsade de Pointes) 03/2024 - 04/2002
23	Polypoidal Choroidal Vasculopathy 07/2023 - 09/2014
15	Macular Degeneration (Age-Related Maculopathy) 03/2024 - 09/2014
13	Atrial Fibrillation 08/2023 - 05/2005
12	Long QT Syndrome 01/2018 - 04/2003
10	Heart Failure 11/2022 - 12/2002
8	Cardiac Arrhythmias (Arrythmia) 01/2021 - 01/2004
8	Neoplasms (Cancer) 01/2018 - 05/2002
7	Tachycardia (Tachyarrhythmias) 01/2023 - 07/2002
7	Heart Arrest (Cardiac Arrest) 01/2023 - 07/2002
7	Bradycardia 04/2022 - 05/2004
6	Hypertension (High Blood Pressure) 04/2022 - 05/2005
6	Infections 12/2011 - 04/2002
5	Ventricular Tachycardia 12/2018 - 04/2002
5	Stomach Neoplasms (Stomach Cancer) 03/2004 - 04/2002
4	Human Influenza (Influenza) 03/2024 - 01/2013
4	Hypotension (Low Blood Pressure) 01/2023 - 08/2017
4	Ventricular Fibrillation 06/2022 - 08/2002
4	Ischemia 01/2021 - 01/2016
4	Gastritis 12/2011 - 02/2003
3	Myocardial Ischemia (Ischemic Heart Diseases) 04/2022 - 01/2016
3	Cardiovascular Diseases (Cardiovascular Disease) 10/2020 - 02/2010
3	Premature Cardiac Complexes (Extrasystoles) 01/2011 - 01/2005
3	Carcinoma (Carcinomatosis) 04/2003 - 10/2002
2	Alzheimer Disease (Alzheimer's Disease) 04/2022 - 01/2021
2	Bipolar Disorder (Manic Depressive Psychosis) 03/2021 - 12/2018
2	Out-of-Hospital Cardiac Arrest 01/2019 - 09/2016
2	Geographic Atrophy 06/2017 - 01/2016
2	Coronary Vasospasm (Coronary Artery Vasospasm) 12/2016 - 08/2016
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2016 - 11/2006
2	Neoplasm Metastasis (Metastasis) 01/2006 - 09/2004
2	Hypoxia (Hypoxemia) 04/2005 - 08/2004
2	Adenocarcinoma 04/2003 - 10/2002

Drug/Important Bio-Agent (IBA)

18	afliberceptIBA 03/2024 - 07/2016
13	Halothane (Fluothane)FDA Link 01/2021 - 08/2002
9	Ranibizumab (Lucentis)FDA Link 09/2021 - 01/2015
8	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 01/2023 - 10/2005
8	Retinaldehyde (Retinal)IBA 04/2021 - 09/2014
5	Oseltamivir (Tamiflu)FDA Link 01/2022 - 01/2013
5	1-phenyl-3,3-dimethyltriazene (PDT)IBA 09/2021 - 01/2017
5	cilnidipineIBA 12/2016 - 10/2004
5	Amiodarone (Amiodarona)FDA LinkGeneric 06/2016 - 08/2002
5	Messenger RNA (mRNA)IBA 01/2011 - 02/2003
4	Bepridil (Vascor)FDA Link 08/2021 - 06/2008
4	Terfenadine (Seldane)IBA 04/2020 - 06/2003
4	nifekalantIBA 01/2014 - 06/2003
4	sparfloxacin (AT 4140)FDA Link 01/2006 - 06/2003
3	Isoflurane FDA LinkGeneric 03/2024 - 01/2022
3	brolucizumabIBA 07/2023 - 09/2021
3	Dronedarone FDA Link 10/2022 - 01/2018
3	Anti-Arrhythmia AgentsIBA 10/2022 - 01/2004
3	Cisapride (Propulsid)FDA Link 08/2021 - 06/2003
3	Moxifloxacin (Avelox)FDA Link 08/2020 - 02/2004
3	Antipsychotic Agents (Antipsychotics)IBA 12/2018 - 01/2017
3	Vasodilator Agents (Vasodilators)IBA 08/2017 - 01/2016
3	Vasopressins (Vasopressin)IBA 12/2016 - 08/2002
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 02/2016 - 07/2002
3	Proteins (Proteins, Gene)FDA Link 01/2012 - 02/2003
3	sematilideIBA 06/2003 - 04/2002
2	CatecholaminesIBA 01/2023 - 10/2004
2	AstemizoleIBA 10/2022 - 06/2016
2	Haloperidol (Haldol)FDA LinkGeneric 10/2022 - 01/2017
2	AVE 0118IBA 08/2022 - 09/2020
2	Donepezil (Aricept)FDA LinkGeneric 04/2022 - 01/2021
2	3-(2-carboxyindol-3-yl)propionic acidIBA 08/2021 - 01/2021
2	Verapamil (Calan)FDA LinkGeneric 08/2021 - 01/2021
2	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2018
2	Fluvoxamine (Luvox)FDA LinkGeneric 10/2019 - 02/2015
2	Adrenergic Receptors (Adrenergic Receptor)IBA 09/2019 - 12/2002
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2017 - 01/2017
2	candesartanIBA 01/2017 - 02/2007
2	Nitroglycerin (Dynamite)FDA LinkGeneric 10/2016 - 08/2002
2	Complement Factor H (Factor H)IBA 08/2016 - 09/2014
2	Cardiotonic Agents (Cardiac Stimulants)IBA 03/2016 - 04/2003
2	ONO-AE1-329IBA 03/2016 - 08/2015
2	CytokinesIBA 01/2015 - 04/2005
2	pilsicainideIBA 01/2013 - 07/2009
2	Ion Channels (Ion Channel)IBA 01/2011 - 06/2008
2	salicylhydroxamic acid (SHAM)IBA 11/2008 - 07/2007
2	Acetylcholine (Acetylcholine Chloride)FDA Link 06/2007 - 07/2002
2	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA 02/2006 - 04/2005
2	Biomarkers (Surrogate Marker)IBA 02/2006 - 10/2004
2	Thymidine PhosphorylaseIBA 01/2006 - 11/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 05/2005 - 02/2004
2	Protein Isoforms (Isoforms)IBA 04/2005 - 08/2004
2	Mexiletine (Mexitil)FDA LinkGeneric 01/2004 - 08/2003
2	Sulpiride (neogama)IBA 06/2003 - 08/2002
1	peramivirIBA 03/2024

Therapy/Procedure

11	Therapeutics 09/2021 - 05/2002
8	Photochemotherapy (Photodynamic Therapy) 09/2021 - 01/2017
5	Injections 03/2024 - 01/2018
5	Cardiopulmonary Resuscitation (CPR) 01/2021 - 08/2002
5	Retreatment 01/2018 - 01/2017
4	Oral Administration 01/2011 - 06/2003
3	Anesthesia 01/2023 - 10/2005
3	Intravitreal Injections 01/2020 - 10/2017
2	Heart Massage 06/2022 - 01/2021
2	Gastrectomy 01/2006 - 05/2002
2	Combination Drug Therapy (Combination Chemotherapy) 08/2002 - 05/2002